There are few possible reasons for this error and one if them (which is the one i encountered) is when you symlink the .PlayOnLinux folder to a NTFS partition. So its a file system issue (Wine is suggesting to not use fuse file-system).
To bypass this error you need to open the PlayOnLinux console. To do that open the terminal and type:
And then execute this command on the PlayOnLinux console:
POL_Config_Write NO_FSCHECK TRUE
Note that after toggling this behavior the team from PlayOnLinux won't support you anymore. So use it only if you have a good reasons for enabling NO_FSCHECK.